Lee Borthwick

Lee Borthwick

Company: Newcastle University

Job title: Fibrosis Biology Lecturer


I completed my PhD at the University of Sheffield and joined Newcastle University in 2005 working as a Research Associate in the Newcastle Fibrosis Research Group (NFRG) under the supervision of Prof. Derek Mann and Prof. Andrew Fisher. In 2011 I was awarded a Marie Curie International Outgoing Fellowship and spent 2 years working in the laboratory of Dr Thomas Wynn at the National Institute of Health in Bethesda. Upon returning to Newcastle I was appointed to a University Research Fellowship role and provided dedicated laboratory space and support to conduct my research. I was promoted to a Lecturer in 2017 and Senior Lecturer in in Fibrosis Biology in 2019. My research primarily focuses on understanding the role of fibroblast plasticity in driving/resolving inflammation and fibrosis. To achieve this goal my laboratory combines in vivo mouse models with the use of precision cut slices (PCS) prepared from human tissue and ex-vivo cultures of human cells. The use of human tissue and cells is helping us to develop new robust laboratory models to study fibrosis that are more relevant to human disease. My current collaborators include Pfizer, Genentech and GlaxoSmithKline. I also serve as Chief Operations Officer and sit on the Board of Directors for FibroFind, a spin-out CRO from the NFRG that provides commercial studies using in vivo fibrosis models as well as our bespoke PCS platform to pharma and other academic institutions.

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